Hydrochlorothiazide: The most common signs and symptoms of overdose observed in human beings are People attributable to electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from extreme diuresis.

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Irbesartan prevents angiotensin II binding to your AT1 receptor in tissues like vascular easy muscle mass and the adrenal gland. Irbesartan and its Energetic metabolite bind the AT1 receptor with 8500 instances much more affinity than they bind on the AT2 receptor.

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If digitalis has also been administered, hypokalemia might accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is eliminated by hemodialysis has not been proven. The oral LD50 of hydrochlorothiazide is larger than 10 g/kg in both mice and rats.

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